化合物SKLB 610 T1895

Product Introduction
Bioactivity


英文名: SKLB 610

描述: SKLB 610 是一种新型多靶点抑制剂，在生化激酶测定中，浓度为 10 μM 时，对血管生成相关酪氨酸激酶 VEGFR2、FGFR2 和 PDGFR 的抑制率分别为 97%、65% 和 55%。

激酶实验: PI3K assay: PI3K assay is preformed on whole-cell lysates from CLL or normal B cells. A PI3K ELISA assay is performed. Briefly, whole-cell extracts are added to a mixture of PI(4,5)P2 substrate and reaction buffer containing adenosine triphosphate (ATP) and allowed to incubate at room temperature. The reaction is stopped by adding PI(3,4,5)P3 detector mixed with EDTA (ethylenediaminetetraacetic acid) and allowed to incubate at room temperature for 1 hour. After this time, the mixture is transferred from each well to a PI3K ELISA plate and allowed to incubate 1 hour. Plates are washed and then incubated with secondary detector for 30 minutes. Plates are washed again, and 3,3′,5,5′-tetramethylbenzidine solution is added for 5 minutes at which time H2SO4 is added to stop all reactions. Plates are read at 450 nm on a Labsystems 96-well plate reader.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (120.37 mM)


关键字: SKLB 610 | SKLB610 | SKLB-610

相关产品: AMG-47a | Capillarisin | SU11274 | Dovitinib | ZM 306416 | VEGFR-2-IN-5 | Regorafenib | MGCD-265 analog | SU14813 maleate | Pz-1

相关库: Cytokine Inhibitor Library | Anti-Cancer Compound Library | Angiogenesis related Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Inhibitor Library | Tyrosine Kinase Inhibitor Library | Reprogramming Compound Library | Anti-Cardiovascular Disease Compound Library | NO PAINS Compound Library

化合物SKLB 610 T1895信息由TargetMol中国为您提供，如您想了解更多关于化合物SKLB 610 T1895报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途