化合物 T19331 T19331

Product Introduction
Bioactivity


英文名: F 16915

描述: F 16915 can prevent heart failure-induced atrial fibrillation.F 16915 is a docosahexaenoic acid derivative.

体内活性: Treatment with F 16915 has no significant effect on body weight: 27.7±2.9 kg and 28.1±1.0 kg before surgery versus 29.2±3.4 kg and 28.8±1.7 kg after in the 1 and 5 g/day groups, respectively.?F 16915 administered at 5 g/day for 4 weeks significantly reduces the mean duration of Atrial fibrillation (AF) induced by burst pacing but has no significant effect at 1 g/day.?The duration of AF is significantly reduced from 989±111 s in the placebo group to 79±59 s in the presence of F 16915 at 5 g/day.?Treatment of 2 months with 100 mg/kg F 16915 also significantly reduces the infarct size.F 16915 is a docosahexaenoic acid derivative which can prevent heart failure-induced atrial fibrillation. Time-dependent changes in blood concentrations of total docosahexaenoic acid (DHA) and nicotinyl alcohol are followed after a single oral administration of F 16915 (300 mg/kg) to male rats.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: F 16915 | F16915 | F-16915

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途