化合物ML347 T1943

Product Introduction
Bioactivity


英文名: ML347

描述: ML347 (LDN 193719) 是一种选择性的 ALK1/ALK2 抑制剂，它们的 IC50 分别为 46/32 nM，比对 ALK3 的抑制性高 300 倍。

激酶实验: Kinase assay: All kinase assays are conducted by Reaction Biology Corp. In brief, compounds are tested at 10 concentrations by 3-fold serial dilutions starting at 30 μM, using nonspecific kinase inhibitor staurosporine as control. In vitro kinase reactions are carried out in the presence of 10 μM (33P)γATP. Five kinases tested are the human BMP type-I receptor activin receptor-like kinase 2 (ALK-2/ACVR1), the human TGFβ type-I receptor activin receptor-like kinase 5 (Alk5/TGFβR1), the human VEGF type-II receptor (KDR/Flk-1/VEGFR2), the human AMP-activated protein kinase (AMPK/A1/B1/G1) and the human platelet-derived growth factor receptor-β (PDGFRβ).

体内活性: 在人类和大鼠血浆中,ML347与血浆蛋白的结合力较高。ML347在BMP应答的C2C12BRA细胞中也有一定效能（IC50：15 nM）。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 7.1 mg/mL (20 mM)


关键字: Inhibitor | Smad1/5 | inhibit | LDN-193719 | ML347 | LDN193719 | TGF-β Receptor | ML 347 | Transforming growth factor beta receptors | ALK1 | ML-347 | ALK2

相关产品: Crizotinib hydrochloride | LDN-214117 | EML4-ALK kinase inhibitor 1 | Ceritinib | LDN-193189 2HCl | ALK2-IN-2 | Lorlatinib | MS4077 | N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline | CEP-28122

相关库: Angiogenesis related Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Tyrosine Kinase Inhibitor Library | Highly Selective Inhibitor Library | Anti-Pancreatic Cancer Compound Library | TGF-beta/Smad Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途