N-羟乙酰神经氨酸 T19456

Product Introduction
Bioactivity


英文名: N-Glycolylneuraminic acid

描述: N-Glycolylneuraminic acid (GcNeu) 是可在猪中合成的非人唾液酸分子。它作为结合甲型流感病毒的诱饵受体起作用。

体外活性: Expression of N-Glycolylneuraminic acid on human cells clearly suppressed infectivity of IAVs that possess N-Glycolylneuraminic acid binding ability. Furthermore, there was no difference in infectivity of a transfectant virus that included the wild-type HA gene from A/Memphis/1/1971 (H3N2), which shows no N-Glycolylneuraminic acid binding, between parent MCF7 cells and cells stably expressing the monkey CMAH gene (CMAH-MCF7 cells). On the other hand, cell entry of the transfectant virus that included the N-Glycolylneuraminic acid-binding HA gene with a single mutation to Tyr at position Thr155 was arrested at the stage of internalization from the plasma membrane of the CMAH-MCF7 cells[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 76 mg/mL (233.65 mM)


关键字: N-Glycolylneuraminic acid | Endogenous Metabolite | Inhibitor | NGlycolylneuraminic acid | inhibit | Influenza Virus | N Glycolylneuraminic acid

相关产品: Iniparib | Triazavirin | Tunicamycin | Anti-Influenza agent 5 | β-Cyclodextrin | 2-PADQZ hydrochloride | Emricasan | Pentagalloylglucose | Chlorogenic Acid | CEF6 acetate(913545-15-0 free base)

相关库: Bioactive Compounds Library Max | Human Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Covalent Inhibitor Library | Anti-Viral Compound Library | Bioactive Compound Library

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