NO-泼尼松龙 T19480

Product Introduction
Bioactivity


英文名: NO-prednisolone

描述: NO-prednisolone (NCX-1015) 是一种有效刺激体内IL-10产生的化合物，是一种释放一氧化氮(NO)的Prednisolone 衍生物。

体外活性: NO-prednisolone (NCX-1015) demonstrates superior effectiveness compared to Prednisolone in reducing inflammation, inhibiting the generation of cytokines and chemokines, and enhancing the expression of the steroid-sensitive cell-surface marker CD163 in human peripheral blood mononuclear cells.[1] Additionally, NO-prednisolone exhibits greater potency than Prednisolone in inducing CD163 cell surface expression. This heightened efficacy of NO-prednisolone, relative to the parent molecule Prednisolone, is also observed in the inhibition of IL-1β production induced by LPS (lipopolysaccharide).[2]

体内活性: In vivo, NO-prednisolone (NCX-1015) potently stimulates IL-10 production, suggesting that the NO steroid induces a regulatory subset of T cells that negatively modulates intestinal inflammation. The two doses of NO-prednisolone tested, 0.5 and 5 mg/kg/day effectively attenuate the severity of the wasting syndrome, ameliorate the colitis score, and reduce the colonic myeloperoxidase (MPO) activity. NO-prednisolone administration also reduces the colonic mRNA and protein content of tumor necrosis factor-α, IL-12, and IFN-γ. NO-prednisolone also reduces the expression of inducible NO synthase and cyclooxygenase-2. In a chronic model of granulomatous tissue inflammation, administration of NCX-1015 (13.9 μmol/kg）can effectively reduce the weight of dry granulomas, while exhibiting a lower anti-angiogenic effect.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 22.5 mg/mL (41.7 mM)


关键字: NCX1015 | NO-prednisolone | NCX 1015

相关产品: Nosantine racemate | Mussaenoside | norbergenin | Febrifugine | Triptoquinone A | IL-4-inhibitor-1 | Rolinsatamab | Abrezekimab | Bakkenolide D | Nudiposide

相关库: Bioactive Compounds Library Max | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途