化合物T807 T19573

Product Introduction
Bioactivity


英文名: T807

描述: T807 (AV-1451) 是新型的tau 正电子发射断层扫描示踪剂。

体外活性: In vitro autoradiography results show that [18F]T807 exhibits strong binding to PHF-tau positive human brain sections with Kd of 14.6 nM. Comparison of autoradiography and double immunohistochemical staining of adjacent sections of PHF-tau and Ab showed that [18F] T807 binding is colocalized with immunoreactive PHF-tau pathology, but does not highlight Ab plaques[1]. [18F]T807 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites. [18F]T807 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions is identified[2].

体内活性: [18F]T807 can cross the blood-brain barrier and ished out quickly in mice models. [18F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 16.6 mg/mL (63.05 mM)


关键字: T-807 | AV1451 | T 807 | Inhibitor | inhibit | AV 1451 | T807

相关产品: Ansamitocin p-3 | Tubulin inhibitor 1 | Tubulin inhibitor 7 | Podophyllotoxone | Taccalonolide A | Leucomethylene blue mesylate | 10-Deacetyl-7-xylosyl paclitaxel | Maytansine | CK-636 | KIF18A-IN-2

相关库: Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Microtubule-Targeted Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Alzheimer's Disease Compound Library | NO PAINS Compound Library | Bioactive Compound Library

化合物T807 T19573信息由TargetMol中国为您提供，如您想了解更多关于化合物T807 T19573报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途