凝血酶 T19580

Product Introduction
Bioactivity


英文名: Thrombin (MW 37kDa)

描述: Thrombin (MW 37kDa) 是一种 Na+激活的胰蛋白酶样别构丝氨酸蛋白酶。它能够利用凝血酶识别序列对融合蛋白进行位点特异性切割，并可用于消化 GST 标记的蛋白。

体外活性: Low concentrations of thrombin and thrombin preconditioning yield the potential of rescuing cells and to induce survival of neurons and astrocytes exposed to various ischemic insults[1].

体内活性: Elevated thrombin activity was found in the brain slices from mice that were treated (in vitro and in vivo) with paraoxon. Increased levels of PAR-1 and pERK proteins and decreased prothrombin mRNA were found in the brains of paraoxon-treated mice. Furthermore, ex vivo and in vivo electrophysiological experiments showed that exposure to paraoxon causes elevated electrical activity in CA1 and CA3 regions of the hippocampus. Moreover, a specific PAR-1 antagonist (SCH79797) reduced this activity. Altogether, these results reveal the importance of thrombin and PAR-1 in paraoxon poisoning[2].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Inhibitor | inhibit | Thrombin (MW 37kDa)

相关产品: Enoxaparin sodium | Imitrodast | Thrombin inhibitor 1 | Eltrombopag | Dabigatran Etexilate Mesylate | AEBSF hydrochloride | Protamine sulfate | Z-Gly-Pro-Arg-4MβNA | p-Hydroxycinnamic acid | Dabigatran ethyl ester

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途