化合物JTE-907 T19705

Product Introduction
Bioactivity


英文名: JTE-907

描述: JTE-907 是一种具有高度选择性和口服活性的 CB2 受体反向激动剂。JTE-907在体内展现出抗炎活性。

体外活性: JTE 907 acts as a Gq-coupled agonist in islets to stimulate insulin secretion and maintain β-cell mass in a GPR55-independent fashion. JTE 907 (10 μM) significantly stimulated insulin secretion from islets isolated from human donors and islets from Gpr55+/+ and Gpr55-/- mice. These stimulatory effects were accompanied by significant elevations of IP1 and [Ca2+]i, but there were no changes in cAMP generation. JTE 907 also significantly reduced cytokine-induced apoptosis in human and mouse islets and promoted human β-cell proliferation.[4]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 112.5 mg/mL (256.6 mM)


关键字: JTE907 | JTE-907

相关产品: SCH-336 | OMDM-6 | A-836339 | Taranabant racemate | CB1R antagonist 1 | Otenabant | (±)-Ibipinabant | Taranabant | AM1241 | Tetrahydrocannabivarin

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途