索玛鲁肽醋酸盐 T19850L

Product Introduction
Bioactivity


英文名: Semaglutide Acetate

描述: Semaglutide Acetate 是胰高血糖素样肽 1 (GLP-1) 受体的激动剂，可用于治疗 2 型糖尿病的研究。

体外活性: Semaglutide Acetate是一种长效GLP-1类似物，其对GLP-1受体的亲和力为0.38 nM[3]。

体内活性: Semaglutide Acetate improves 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced motor impairments. Semaglutide Acetate rescues the decrease of tyrosine hydroxylase (TH) levels, reduces lipid peroxidation, inhibits the apoptosis pathway, alleviates the inflammation response, increases autophagy-related protein expression, and protects dopaminergic neurons in the substantia nigra and striatum[2]. In mini-pigs, The plasma half-life of Semaglutide Acetate (i.v.) is 46h and the MRT of Semaglutide Acetate (s.c.) is 63.6h[3].

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : <0.05 mg/mL (insoluble)
DMSO : 4.17 mg/mL (1 mM)


关键字: Semaglutide Acetate

相关产品: GLP-1(7-36), amide | Oxyntomodulin acetate | Tirzepatide | PF-06882961 | V-0219 hydrochloride | 6α-Methylprednisolone 21-hemisuccinate sodium salt | Albiglutide TFA (782500-75-8 free base) | 3-Deoxyglucosone | GLP-1 receptor agonist 9 | Glucagon (19-29), human acetate

相关库: Peptide Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途