小构树醇B T20232
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 99624-27-8 | ¥12,100.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Kazinol B
描述: Kazinol B 是一氧化氮(NO)产生的抑制剂,是一种具有二甲基吡喃环的异戊烯化黄烷。Kazinol B 通过激活胰岛素-Akt 信号途径和AMPK,增强葡萄糖摄取,从而改善胰岛素敏感性。Kazinol B 刺激脂肪素的基因表达和分泌,可用于研究糖尿病。
体外活性: Kazinol B (2-20 μM ; 5 days) dose-dependently increases PPARγ and C/EBPα protein and mRNA levels in MDI-treated 3T3-L1 adipocytes.[1] Kazinol B (10-20 μM ; pre-treated for 1 h followed by 1 h insulin) dose-dependently increases insulin-dependent Akt phosphorylation.[1] Kazinol B (2, 10 and 20 μM ; 72 hours) shows no toxicity to adipocytes in 3T3-L1 cells.[1] Kazinol B (2-20 μM ; 72 hours) dose-dependently increases lipid accumulation by 2.4-fold (at 20 μM) treatment as compared with MDI-treated cells.[1] Kazinol B (2-20 μM ; 24 hours) increases the retained 2ʹNBDG-fluorescence in cells in a dose-dependent manner in differentiated 3T3-L1 adipocytes and C2C12 myoblasts.[1] Kazinol B dependently increases the MDI-stimulated GLUT4 mRNA level up to 4.7-fold as compared with MDI-only treated cells.[1] Kazinol B (6.25, 12.5, 25, 50 μM ; 18 hours) dose-dependently reduces amounts of iNOS protein in macrophages (RAW 264.7 cells) activated by LPS (1 ug/mL).[2]
存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : Soluble
关键字: Kazinol B
相关产品: Marein | Hu7691 | AKT inhibitor VIII | Guggulsterone | Atractylenolide II | Kihadanin B | (±)-Praeruptorin A | AKT Kinase Inhibitor HCl | Communic acid | Alphitolic acid
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途