新生霉素 T20510
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 303-81-1 | ¥870.00 | 询底价 |
5 mg | 303-81-1 | ¥580.00 | 询底价 |
100 mg | 303-81-1 | ¥3,540.00 | 询底价 |
1 mg | 303-81-1 | ¥265.00 | 询底价 |
25 mg | 303-81-1 | ¥1,570.00 | 询底价 |
50 mg | 303-81-1 | ¥2,360.00 | 询底价 |
500 mg | 303-81-1 | ¥7,790.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Novobiocin
描述: Novobiocin 是一种具有口服活性和有效性的的抗生素。Novobiocin 是 DNA 促旋酶抑制剂和热休克蛋白 90 (Hsp90) 拮抗剂,对促旋酶和Hsp90 具有抑制作用。 Novobiocin 具有抗正痘活性,可用于研究高度耐药性肺炎球菌感染。
体外活性: Novobiocin (1 mM) competitively hinders the binding of ATP to gyrase B, disrupting nucleotide binding, and impairs the interaction between the co-chaperones Hsc70 and p23 with Hsp90.[1]Novobiocin (200 µM; 24 h) results in the inhibition of the repair rate of DNA interstrand cross-links induced by both cisplatin (cis-DDP) and BCNU. This is accompanied by a corresponding reduction in the clonogenic survival of human glioblastoma multiforme cells.[2]Novobiocin (0.3 mM; 48 hours) triggers caspase-3/7 enzyme-dependent apoptosis assays, resulting in an approximate three- to fivefold increase in the number of apoptotic cells in K562, HL60, and Mutz-2.[5]
体内活性: Novobiocin (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24, and 48 h after infection; Adult female Swiss mice (30g) with sepsis induced by the penicillin-susceptible strain (AR33118)) shows anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.[3]
存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : Soluble
关键字: Novobiocin
相关产品: L-Cystathionine | Euphorbia factor L1 | SC144 | Epothilone A | BTR-1 | Calcium dobesilate | Penicillic acid | Gemcitabine elaidate | Ro 90-7501 | SCR7 pyrazine
相关库: Drug Repurposing Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途