丹参酸 B 镁 T20793
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 122021-74-3 | ¥2,490.00 | 询底价 |
10 mg | 122021-74-3 | ¥3,680.00 | 询底价 |
1 mL | 122021-74-3 | ¥3,970.00 | 询底价 |
1 mg | 122021-74-3 | ¥933.00 | 询底价 |
50 mg | 122021-74-3 | ¥7,920.00 | 询底价 |
100 mg | 122021-74-3 | ¥10,600.00 | 询底价 |
25 mg | 122021-74-3 | ¥5,880.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Magnesium Lithospermate B
描述: Magnesium Lithospermate B 是一种咖啡酸四聚体的衍生物,从Salviae miltiorrhizae 中提取得到。它能够抑制神经炎症并减轻神经变性。它被广泛用于心血管疾病的研究,并且可以防止葡萄糖引起的细胞内氧化损伤。
动物实验: Adult male Sprague-Dawley rats were subjected to an endovascular perforation process to produce an SAH model.?MLB was administrated intraperitoneally at 30min after SAH with a dose of 25mg/kg or 50mg/kg[1].
体外活性: magnesium lithospermate B (MLB) dose-dependently inhibited the activation of microglia and reduced neuronal apoptosis.?Western blot analysis showed that MLB decreased the expression of inflammatory cytokine TNF- and pro-apoptotic protein cleaved caspase-3.?More importantly, MLB increased the expression of SIRT1, while inhibited the acetylation of NF-B.?Furthermore, pretreatment with sirtinol (a selective inhibitor of SIRT1) reversed all the aforementioned effects of MLB after SAH[1].
体内活性: Magnesium Lithospermate B (MLB),一种从丹参中提取的活性成分,在多种中枢神经系统损伤中表现出神经保护作用。研究表明,MLB的给药显著减轻了蛛网膜下腔出血(SAH)[1]后的脑水肿和神经功能障碍。
存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 7.41 mg/mL (10 mM)
关键字: tetramer | oxidative | cardiovascular | Salviae | neuroin?ammation | miltiorrhizae | inhibit | acid | Magnesium Lithospermate B | diseases | caffeic | Inhibitor | damage
相关库: Anti-Aging Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Oxidation-Reduction Compound Library | Selected Plant-Sourced Compound Library | Covalent Natural Product Library | Bioactive Compounds Library Max | Anti-Diabetic Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Natural Product Library
丹参酸 B 镁 T20793信息由TargetMol中国为您提供,如您想了解更多关于丹参酸 B 镁 T20793报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途