马来酸氨氯地平 T21263

Product Introduction
Bioactivity


英文名: Amlodipine maleate

描述: Amlodipine maleate (Amvaz) 是一种具有口服活性的二氢吡啶类钙通道阻滞剂，通过阻滞电压依赖性 L 型钙通道，从而抑制钙离子内流。Amlodipine maleate 可用于研究高血压和癌症。

体外活性: Amlodipine maleate (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells.[4]Amlodipine maleate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% in A431 cells, respectively.[4]Amlodipine maleate (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells.[4]

体内活性: Amlodipine maleate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice.[4]Amlodipine maleate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice.[5]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 108.0 mg/mL (205.7 mM)


关键字: Amlodipine Maleate | Amlodipine (+-)-form Maleate

相关产品: Aranidipine | Didrovaltrate | NecroX-5 | 1-Octanol | Otilonium bromide | ZSET1446 | O-1602 | Myr-TAT-CBD3 | TMDJ-035 | Pinocembrin chalcone

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library | EMA Approved Drug Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途