糠酸氟替卡松 T21404

Product Introduction
Bioactivity


英文名: Fluticasone furoate

描述: Fluticasone furoate (Avamys) 是一种合成的三氟化皮质类固醇，衍生自氟替卡松，Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。

体外活性: Fluticasone furoate displays great potency in inhibiting tumor necrosis factor synthesis and action. Fluticasone furoate prevents damage to cultured human lung epithelial cells by different stimuli[2].

体内活性: Fluticasone furonate is excreted mainly in the feces, with only minor amounts in the urine. Fluticasone furonate is 99.4% bound to plasma protein in vitro. Clearance of Fluticasone furonate is primarily by hydrolysis in the liver by the cytochrome P450 isozyme CYP3A4 that converts the drug to the 17β-carboxylic acid metabolite, which displays low glucocorticoid receptor agonist potency[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : Insoluble
DMSO : 95 mg/mL (176.39 mM)


关键字: Inhibitor | fluorinated | lipophilic | rhinitis | CYP3A4 | inhibit | intranasal | allergic | corticosteroid | Fluticasone Furoate | anti-asthmatic | Anti-inflamatory | Glucocorticoid Receptor

相关产品: Glucocorticoid receptor agonist-1 | Osilodrostat | Prednisolone disodium phosphate | Triamcinolone acetonide | Medrysone | Dexamethasone Phosphate disodium | Fluticasone (propionate) | Megestrol acetate | Esaxerenone | TPI-1

相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Clinical Compound Library | Pediatric Drug Library | Nuclear Receptor Compound Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library | Orally Active Compound Library | Bioactive Compound Library

糠酸氟替卡松 T21404信息由TargetMol中国为您提供，如您想了解更多关于糠酸氟替卡松 T21404报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途