γ-亚麻酸甲酯 T21504

Product Introduction
Bioactivity


英文名: γ-Linolenic Acid methyl ester

描述: γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) 是一种弱白三烯 B4 (LTB4) 受体拮抗剂。

体外活性: γ-Linolenic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA was identified as an ω-6 fatty acid which could be elongated to arachidonic acid for endogenous eicosanoid synthesis. GLA was found to be a weak leukotriene B4 (LTB4) receptor antagonist, which was able to inhibit [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 μM

体内活性: In an in-vivo model of LTB4-induced bronchoconstriction, γ-Linolenic acid methyl ester at a 1 mg/kg i.v. dose could result in 53% inhibition, indicating that essential fatty acids are LTB4 receptor antagonists, which may account in part for reported anti-inflammatory activities.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: dimethyl formamide : 100mg/ml (341.88 mM)
DMSO : 100mg/ml (341.88 mM)


关键字: γ Linolenic Acid methyl ester | r-Linolenic Acid methyl ester | gamma-Linolenic Acid methyl ester | γLinolenic Acid methyl ester | γ-Linolenic Acid methyl ester

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相关库: Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Natural Product Library for HTS | Target-Focused Phenotypic Screening Library | NO PAINS Compound Library | Natural Product Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途