化合物RN-1 dihydrochloride T21652

Product Introduction
Bioactivity


英文名: RN-1 dihydrochloride

描述: RN-1 dihydrochloride 是血脑屏障通透性的、不可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 选择性抑制剂，IC50为 70 nM，对 LSD1 的选择性高于 MAO-A 和 MAO-B，IC50分别为 0.51 μM 和 2.785 μM。

体外活性: RN-1 dihydrochloride 对LSD1的选择性高于MAO-A和MAO-B，其半抑制浓度（IC50）分别为0.51 μM及2.785 μM[3]。

体内活性: In sickle cell disease (SCD) mice, RN-1 dihydrochloride (3-10 mg/kg; i.p.) effectively induces fetal hemoglobin (HbF) levels in red blood cells and reduces disease pathology[1]. In C57BL/6 male mice, after administration of RN-1 dihydrochloride (10 mg/kg, i.p.), concentrations are detectable up to 24 h post dose in both plasma and brain tissues. RN-1 dihydrochloride significantly impairs long-term memory, but not short-term memory. The brain/plasma exposure ratio is 88.9[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 18 mg/mL (39.79 mM)


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相关产品: KDM4D-IN-1 | GSK-J1 | LSD1-UM-109 | Tranylcypromine (2-PCPA) hydrochloride | Acetyl Pentapeptide-1 acetate | LSD1-IN-5 | Procaine hydrochloride | LSD1-IN-30 | KDM5A-IN-1 | ML324

相关库: Mitochondria-Targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Epigenetics Compound Library | Histone Modification Compound Library | Bioactive Compound Library

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