化合物1,4-DPCA T21653

Product Introduction
Bioactivity


英文名: 1,4-DPCA

描述: 1,4-DPCA 是一种脯氨酰羟化酶抑制剂，对人源包皮成纤维细胞中胶原羟基化的 IC50 为 2.4 μM，对因子抑制 HIF (FIH) 的 IC50 为 60 μM。

体外活性: 1,4-DPCA significantly reduces the colony sizes and invasive branches of T4-2 (10 μM) and ZR-75-1 cells (20 μM). 1,4-DPCA inhibits the proliferation in T4-2, ZR-75-1, MDA-MB-231 cells, and MDA-MB-157[1]. In mouse B6 cells, 1,4-DPCA specifically increases the expression of proangiogenic target genes including Hmox1 and Vegfa, and proglycolytic targets including Ldh-a, Pdk1, Glut1, and Pgk1[2].

体内活性: In mice, 1,4-DPCA effectively inhibits collagen deposition within and on the outer surface of the disc, and limits connective tissue ingrowth. 1,4-DPCA suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) discs implanted in the peritoneal cavity[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 2.78 mg/mL (11.56 mM)


关键字: HIF-PH | HIF/HIF Prolyl-Hydroxylase | HIF-1α | HIFs | FIH | P4HA1 | P4HA2 | 1,4DPCA | healing | 1,4-DPCA | Inhibitor | Hypoxia-inducible factors | 1,4 DPCA | wound | inhibit | P4HA3

相关产品: IOX4 | AKBA | dencichine | PT2399 | Velutin | LW6 | DMOG | HIF-2α-IN-4 | Ethyl 3,4-dihydroxybenzoate | Chloramphenicol

相关库: Anti-Cancer Metabolism Compound Library | Transcription Factor-Targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Metabolism Compound Library | Glycolysis Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途