化合物SP 141 T21773
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 1253491-42-7 | ¥913.00 | 询底价 |
5 mg | 1253491-42-7 | ¥828.00 | 询底价 |
100 mg | 1253491-42-7 | ¥5,490.00 | 询底价 |
1 mg | 1253491-42-7 | ¥366.00 | 询底价 |
50 mg | 1253491-42-7 | ¥3,860.00 | 询底价 |
25 mg | 1253491-42-7 | ¥2,630.00 | 询底价 |
10 mg | 1253491-42-7 | ¥1,330.00 | 询底价 |
Product Introduction
Bioactivity
英文名: SP-141
描述: SP-141 是一种 MDM2 抑制剂,可促进 MDM2 自身泛素化和降解,具有抗癌活性。
体外活性: SP141, which bound directly to MDM2, promoting its auto-ubiquitination and degradation by the proteasome.?The compound reduced levels of MDM2 in pancreatic cancer cell lines, as well as their proliferation, with 50% inhibitory concentrations <0.5 μM (0.38-0.50 μM).?Increasing concentrations of SP141 induced increasing levels of apoptosis and G2-M-phase arrest of pancreatic cancer cell lines, whether or not they expressed functional P53[1].
体内活性: Injection of nude mice with SP141 (40 mg/kg/d) inhibited growth of xenograft tumors (by 75% compared with control mice), and led to regression of orthotopic tumors[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 4.4 mg/mL (13.56 mM)
关键字: pancreatic | inhibit | Inhibitor | cancer | MDM-2/p53 | breast | degradation | SP-141 | SP141 | auto-ubiquitination
相关产品: Alrizomadlin | XI-006 | SAR405838 | Ganoderic acid X | Serdemetan | Nutlin-3b | AM-8735 | PhiKan 083 | RO-5963 | NSC 66811
相关库: Anti-Cancer Metabolism Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Lung Cancer Compound Library | Ubiquitination Compound Library | Inhibitor Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Active Compound Library | Anti-Pancreatic Cancer Compound Library | NO PAINS Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途