硫酸卡那霉素 T21820

Product Introduction
Bioactivity


英文名: Resistomycin

描述: Resistomycin（Geliomycin），一种五环多酮类抗生素，通过触发凋亡展现出强大的抗癌特性。

体外活性: Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation. Resistomycin displays a high affinity for GST-Pellino-1 (KD = 2.58 μM) as indicated by surface plasmon resonance[1]. Resistomycin treatment reduced the expression of SNAIL and SLUG in TNBC cells[1]. Resistomycin induced apoptosis and cycle arrest in human hepatocellular carcinoma cells by activating p38 MAPK pathway in vitro and in vivo[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.33 mg/mL (8.86 mM)


关键字: Resistomycin

相关产品: Methicillin sodium salt | Naftifine hydrochloride | Bruceine A | Oligomycin A | Mafenide Acetate | Ciprofloxacin EP IMpurity A | Chloroquine phosphate | Aminothiazole | Clofoctol | Selenium sulfide

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途