化合物DC_AC50 T21876
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 497061-48-0 | ¥4,530.00 | 询底价 |
500 mg | 497061-48-0 | ¥9,450.00 | 询底价 |
25 mg | 497061-48-0 | ¥1,980.00 | 询底价 |
2 mg | 497061-48-0 | ¥449.00 | 询底价 |
1 mg | 497061-48-0 | ¥319.00 | 询底价 |
50 mg | 497061-48-0 | ¥3,160.00 | 询底价 |
5 mg | 497061-48-0 | ¥690.00 | 询底价 |
1 mL | 497061-48-0 | ¥776.00 | 询底价 |
10 mg | 497061-48-0 | ¥996.00 | 询底价 |
Product Introduction
Bioactivity
英文名: DC_AC50
描述: DC_AC50 是一种 Atox 和 CCS 的双抑制剂,是一种抑制细胞内铜伴侣作为减少/预防获得性化疗耐药性的手段。它与 Atox1 和 CCS 结合并减少癌细胞增殖和肿瘤生长。
体外活性: DC_AC50 synergised with carboplatin in combination treatment of human and canine OSA cells to reduce cancer cell viability.?DC_AC50-treated cells were significantly less mitotically active, as demonstrated by decreased expression of phospho-histone H3 and cell cycle analysis.?DC_AC50 also potentiated carboplatin-induced apoptosis in OSA cells and decreased clonogenic survival.?Finally, DC_AC50 reduced the migratory ability of OSA cells.?These results justify further investigation into inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 25 mg/mL (58.93 mM)
关键字: DC_AC-50 | resistance | osteosarcoma | CCS | copper | chaperones | Atox1 | inhibit | Apoptosis | Chemotherapy | DC_AC50 | Inhibitor
相关产品: Nelarabine | Raddeanin A | Candesartan Cilexetil | PHA-665752 | MK-8745 | Karanjin | Diallyl Trisulfide | Trabectedin | Alofanib | Geniposidic Acid
相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | Cuproptosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途