化合物 T21898 T21898

Product Introduction
Bioactivity


英文名: MI-192

描述: MI-192 是一种选择性 HDAC2和 HDAC3抑制剂，IC50分别为 30 nM 和 16 nM。MI-192 比其他 HDAC 异构体对 HDAC2/3 具有更高选择性。MI-192 诱导髓系白血病细胞凋亡 (apoptosis)。抗癌和神经保护活性。

体外活性: MI-192 (0.15-1 μM; 72 h) induces differentiation and is cytotoxic by promoting apoptosis in acute myeloid leukaemic cell lines U937, HL60 and Kasumi-1 [1]. Apoptosis Analysis [1] Cell Line: HL60 and Kasumi-1 cells Concentration: 150 nM, 300 nM, 500 nM, 1 μM Incubation Time: 72 h Result: Induced a substantial degree of apoptosis in both HL60 and Kasumi-1 cells.

体内活性: MI-192 (40 mg/kg; i.p; once a day; for 3 days) exhibits the neuroprotective activity in the mouse brain subjected to photothrombotic stroke [2]. Animal Model: Adult male outbred mice CD-1 (20-25 g) with photothrombotic stroke (PTS) [2] Dosage: 40 mg/kg Administration: i.p; once a day; for 3 days Result: Reduced the volume of the PTS-induced infarction core in the mouse brain, partly restored the functional symmetry in the forelimb use, decreased the level of PTS-induced apoptosis and acetylation of α-tubulin characteristic for stable microtubules, and increased the expression of GAP-43 in the cerebral cortex of the damaged hemisphere.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: MI192 | MI-192 | MI 192

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途