化合物TBCA T21915

Product Introduction
Bioactivity


英文名: TBCA

描述: TBCA (Casein Kinase II Inhibitor III, TBCA) 是高选择性的酪蛋白激酶II CK2 抑制剂，IC50 为 110 nM，Ki 为 77 nM。TBCA 对 CK1、DYRK1A 和 其它 27 个激酶表现出选择性。

体外活性: TBCA inhibits CK2 double mutant (Val66 Ile174) with an IC50 of 0.68 μM. TBCA (0-100 μM; 24 hours) shows a drastic effect on Jurkat cells viability [1]. TBCA dose-dependently inhibits platelet aggregation and secretion induced by various agonists including CRP, 2-MeSADP, AYPGKF and SFLLRN. TBCA also inhibits phosphorylation of PDK1, Akt, and GSK3β induced by AYPGKF[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (97.04 mM)


关键字: TBCA

相关产品: Longdaysin | Casein kinase 1δ-IN-8 | CK1-IN-3 | PF-4800567 | Casein kinase 1δ-IN-6 | Silmitasertib | AS-252424 | A-3 hydrochloride | PF-5006739 | WAY-297174

相关库: Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Highly Selective Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途