化合物PD 198306 T21980

Product Introduction
Bioactivity


英文名: PD 198306

描述: PD 198306 是一种具有抗痛觉过敏作用的 MAPK/ERK 激酶 (MEK) 选择性抑制剂。 PD 198306 可降低链脲佐菌素诱导的活性 ERK1 水平升高。

体外活性: PD 198306（10 μM）在18小时和36小时时，分别降低了Tha-Crimson复制30%和50%。同样，PD 198306（10 μM）显著抑制了Tha-GFP复制25%[1]。

体内活性: In male Sprague Dawley rats bearing neuropathic pain, PD 198306 (1-30 μg/10 μL; i.t.) dose-dependently blocks static allodynia in both the chronic constriction injury and the streptozocin models[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (94.49 mM)


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相关产品: GW 284543 hydrochloride | TAK-285 | BMS-599626 | Trametinib | APS-2-79 hydrochloride | Corylifol C | URMC-099 | AZD8330 | Ro 5126766 | Isorhamnetin

相关库: Anti-Prostate Cancer Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Colorectal Cancer Compound Library | Anti-Obesity Compound Library | Bioactive Compound Library

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