化合物AGK7 T22026

Product Introduction
Bioactivity


英文名: AGK7

描述: AGK7 是 sirtuin 2 (SIRT2) 抑制剂。它在体外和帕金森病果蝇模型中均能抑制多巴胺能细胞的凋亡。在帕金森病细胞模型中，它改善了 α-突触核蛋白毒性和修饰的包涵体形态

体外活性: AGK2 is a selective SIRT2 inhibitor with IC50 value of 3.5 μM. AGK2 slightly inhibited SIRT1 and 3 only at concentrations over 40 μM. Relative to an inactive control AGK7, AGK2 increased acetylated tubulin. In H4 cells transfected with α-Syn, AGK2 reduced α-Syn-mediated toxicity in a dose-dependent way. By contrast, the inactive AGK7 had no effect. In H4 cells cotransfected withα-Syn and synphilin-1, the inactive AGK7 failed to affect a-Syn aggregation, whereas AGK2 promoted the formation of enlarged inclusions [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 0.5 mg/mL


关键字: Parkinson's disease | sirtuin 2 | morphology | SIRT2 Inhibitor,Inactive Control | Drosophila | inhibit | toxicity | Inhibitor | alpha-synuclein | dopaminergic cell death | AGK7 | AGK 7 | AGK-7 | Sirtuin

相关产品: Selisistat S-enantiomer | MC3482 | Thiomyristoyl | SRT 1720 dihydrochloride[925434-55-5(free base)] | WAY-270360 | Cambinol | WAY-354574 | Tenovin-6 Hydrochloride | HSP70/SIRT2-IN-1 | YM-08

相关库: Epigenetics Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途