双氢链霉索 T2211
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 mg | 5490-27-7 | ¥423.00 | 询底价 |
1 g | 5490-27-7 | ¥498.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Dihydrostreptomycin sulfate
描述: Dihydrostreptomycin sulfate (Dihydrostreptomycin sesquisulfate) 是一种氨基糖苷类抗生素,可研究牛、猪和羊的细菌性疾病。
激酶实验: Briefly, the peptide substrate N-acetyl-Asp-Glu-Val-Asp-ρ-nitroanilide (Ac-DEVD-ρNA) is added to the cell lysates in assay buffer (50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 10 mM dithiothreitol, 1 mM EDTA, 10% glycerol) and incubated at 37°C. The cleavage of the substrate is monitored at 405 nm.
体外活性: The primary mechanism of action of the antibiotic dihydrostreptomycin is binding to and modifying the function of the bacterial ribosome, thus leading to decreased and aberrant translation of proteins. It enters bacterial cells by binding to a specific site on MscL(mechanosensitive channel of large conductance) and modifying its conformation, thus allowing the passage of K+ and glutamate out of, and dihydrostreptomycin into, the cell[1].
体内活性: Dihydrostreptomycin sulfate 会导致小鼠模型耳蜗损伤,而在Dihydrostreptomycin sulfate 诱发损伤后,螺旋韧带中的细胞可能会发生增殖。这一过程可能与耳蜗功能的恢复有关[2]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : 10 mM
DMSO : Insoluble
关键字: inhibit | Dihydrostreptomycin Sulfate | Dihydrostreptomycin sulfate | Inhibitor | Antibiotic | Dihydrostreptomycin | Bacterial
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相关库: Drug Repurposing Compound Library | Approved Drug Library | Antibiotics Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | Anti-Bacterial Compound Library | Microbial Natural Product Library | NO PAINS Compound Library | Anti-Infection Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途