化合物NQTrp T22118
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 185351-19-3 | ¥1,580.00 | 询底价 |
2 mg | 185351-19-3 | ¥495.00 | 询底价 |
5 mg | 185351-19-3 | ¥828.00 | 询底价 |
Product Introduction
Bioactivity
英文名: NQTrp
描述: NQTrp 是芳香萘醌-色氨酸杂交分子,可以抑制 tau 蛋白的聚集,具有抗淀粉样蛋白活性。NQTrp 对六肽 (41GCWMLY46,γD-crystallin 的 N 端)和全长 γD-crystallin 的体外聚集有抑制作用。
体外活性: NQTrp inhibits the in vitro aggregation of hexapeptide (41GCWMLY46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin. NQTrp effectively inhibits the fibrillation of the GDC6 peptide (50 μM) in a dose-dependent manner and prevents the formation of elongated amyloid fibrils[1]. NQTrp has no toxic effect toward retinal cell culture and reduces the cytotoxicity induced by aggregates of the hexapeptide(IC50=70 μM) in ARPE-19 cells. In TEM analysis, GDC6 peptide fibrils (50 μM) in the presence of NQTrp 5:1, 1:1, 1:5 ratio (GDC6: NQTrp)[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 125 mg/mL (346.88 mM)
关键字: Microtubule/Tubulin | Inhibitor | aggregation | inhibit | fibrils | Tau Protein | hexapeptide | γD-crystallin | amyloidogenic | NQTrp
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途