特康唑 T2213

Product Introduction
Bioactivity


英文名: Terconazole

描述: Terconazole (Terazol 7) 是一种广谱抗真菌药物，用于研究阴道酵母菌感染。

体外活性: Terconazole inhibits the growth of Candida albicans ATCC 44859 in a concentration-related manner but has modest effects at levels of 0.1 to 10 μM when the yeast is grown on media that favors the cell form. The inhibitory potency of terconazole on yeast cell viability varies with the strain and species of Candida tested. The susceptibility of C. albicans ATCC 44859 to terconazole is markedly enhanced when the yeast is grown on Eagle minimum essential medium, which favors mycelium formation. There is a progression of changes, from loss of mycelia formation at 0.1 μM terconazole through complete necrosis at 100 μM[1]. Terconazole blocks the morphogenetic transformation from the yeast into the filamentous form at concentrations of 0.008 to 0.05 microgram/mL[2].

体内活性: A 3-day once-daily intravaginal application of terconazole 0.8% is usually sufficient to provide a functional therapeutic period of 7 days due to prolonged high biologically active antifungal levels in the vagina. No side effects are observed at any concentration of terconazole[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL(84.5 mM)


关键字: inhibit | Terconazole | Inhibitor | Fungal | R-42470 | R 42470

相关产品: (-)-Corynoxidine | Cheilanthifoline | Coronarin E | Odorinol | Atalantoflavone | De-O-methyllasiodiplodin | Sulochrin | (+)-Medioresinol | Isoapetalic acid | Taxoquinone

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | FDA-Approved & Pharmacopeia Drug Library | Human Metabolite Library | Inhibitor Library | Pediatric Drug Library | Anti-Fungal Compound Library | Anti-Infection Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途