二氯美维库铵 T22371

Product Introduction
Bioactivity


英文名: Mivacurium dichloride

描述: Mivacurium dichloride (Mivacurium chloride) 是苄基异喹啉衍生物，可与 nAChR 偶联，以减少或抑制乙酰胆碱对肌肉细胞末端盘的去极化作用。它也是非去极化短效的神经肌肉阻滞剂和骨骼肌松弛剂。

体外活性: Mivacurium caused pseudo-allergic reactions in wild-type mice by inducing mast cells to release histamine.?However, it did not induce a similar phenomenon in KitW-sh/W-sh mice.?Furthermore, MrgprB2-knockout mice displayed no inflammatory response to mivacurium.?Mivacurium induced LAD2 cell degranulation in a dose-dependent manner.?Mivacurium stimulated intracellular calcium ion (Ca2+) influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells.?However, mivacurium induced the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering (si)RNA.?Notably, cytokine release was not observed in LAD2 cells even when stimulated with high concentrations of mivacurium[1].

体内活性: Mivacurium is rapidly hydrolyzed in the plasma with a short duration of action(< 10 min). Mivacurium has lots of advantages, like a rapid effect, nonneurological toxicity and a lack of heart rate alteration. Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature[1]. 

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 100 mg/ml (90.9 mM)
DMSO : 100 mg/ml (90.9 mM)
H2O : 100 mg/ml (90.9 mM)


关键字: skeletal | nAChR | inhibit | muscle | Nicotinic acetylcholine receptors | Inhibitor | Mivacurium Dichloride | Short-duration | Mivacurium dichloride | non-depolarizing | neuromuscular | relaxant | Mivacurium | steroidal | Mivacurium Chloride | benzylisoquinoline

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