化合物5-BDBD T22518

Product Introduction
Bioactivity


英文名: 5-BDBD

描述: 5-BDBD 是选择性P2X4受体拮抗剂，抑制 rP2X4R 介导的电流，IC50为0.75μM。它可完全阻断硝酸甘油诱导的基础性和急性痛觉过敏。

动物实验: 5-BDBD (28 mg/kg; i.p.; daily for 9 days; male C57BL/6 mice) prevented NTG-induced mechanical hypersensitivity[2].

体外活性: 5-BDBD could be specifically used to discriminate between P2X1R, P2X2aR, P2X2bR, P2X3R, P2X4R, and P2X7R[1]. 5-BDBD inhibits 10 μM ATP-induced currents of rP2X4R-expressing HEK293 cells in a concentration-dependent manner, with an IC50 of 0.75 μM[1]. 5-BDBD displaces rightward the ATP concentration-response curve, with an EC50 of 4.7 to 15.9 μM[1].

体内活性: 通过反复注射NTG引起的基础性痛觉过敏完全被5-BDBD[2]阻断。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/mL (168.92 mM)


关键字: inhibit | P2X Receptor | P2XRs | currents | NTG | hyperalgesia | selective | Inhibitor | 5-BDBD | ATP | 5BDBD | acute | 5 BDBD

相关产品: ATP disodium salt | A 438079 hydrochloride | P2X3-IN-1 | AZD9056 hydrochloride | NF023 hexasodium | Indophagolin | Minodronic acid | NP-1815-PX | A-740003 | AF-353

相关库: Ion Channel Inhibitor Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途