6-羟基褪黑素 T22530
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 63762-74-3 | ¥7,790.00 | 询底价 |
1 mg | 63762-74-3 | ¥2,350.00 | 询底价 |
500 mg | 63762-74-3 | ¥34,800.00 | 询底价 |
100 mg | 63762-74-3 | ¥17,500.00 | 询底价 |
25 mg | 63762-74-3 | ¥11,200.00 | 询底价 |
5 mg | 63762-74-3 | ¥5,630.00 | 询底价 |
50 mg | 63762-74-3 | ¥13,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: 6-Chloromelatonin
描述: 6-Chloromelatonin 是一种有效的褪黑素受体 (melatonin receptor) 激动剂,是一种5-甲氧基吲哚化合物,可竞争兔视网膜中相同的突触前褪黑激素受体位点 ,可抑制[3H]多巴胺的钙依赖性释放 具有比褪黑素更高的代谢稳定性。6-Chloromelatonin 竞争 [3H] 褪黑素 与 MT2 受体结合 (pKi=9.77),可能用于研究与抑郁症相关的失眠和睡眠障碍。
体外活性: 6-Chloromelatonin (10 pM, 1 nM, 100 nM, 10 μM; 72 h) inhibits forskolin-stimulated hCG-beta secretion in JEG-3 and BeWo cells in a dose-dependent manner but had no effect on basal human chorionic gonadotrophin (hCG-beta) levels.[4] 6-Chloromelatonin competes for [3H]-melatonin binding sites in human platelet (Ki=11.4 nM).[3]
体内活性: 6-Chloromelatonin (0.5 mg/kg; injection; rats) on the day after the phase shift has markedly higher excretion rates of 6-Sulphatoxymelatonin compared with controls.[5]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 90.0 mg/mL (337.4 mM)
关键字: 6-Chloromelatonin | 6 Chloromelatonin | 6Chloromelatonin
相关产品: Agomelatine | ACH-000143 | Ramelteon | 2-Iodomelatonin | Luzindole | 4-P-PDOT | Melatonin | Tasimelteon | N-ACETYLTRYPTAMINE
相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途