9-羟基菲 T22537

Product Introduction
Bioactivity


英文名: 9-Phenanthrol

描述: 9-Phenanthrol 是瞬时受体电位 melastatin 4 (TRPM) 通道的抑制剂，这是一种 Ca2+ 激活的非选择性阳离子通道。

体外活性: In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC(50). Channel inhibition was voltage independent. The IC(50) determined in the whole-cell and inside-out experiments were similar, suggesting a direct effect of the molecule. However, 9-phenanthrol was ineffective on TRPM5, the most closely related channel within the TRP protein family. We identify 9-phenanthrol as a TRPM4 inhibitor, without effects on TRPM5. It could be valuable in investigating the physiological functions of TRPM4, as distinct from those of TRPM5[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 19 mg/mL (97.82 mM)
Ethanol : 9 mg/mL (46.34 mM）


关键字: ischemia-reperfusion injury | inhibit | TRPM4 | NSC-50554 | 9Phenanthrol | Inhibitor | NSC 50554 | TRP Channel | 9-Hydroxyphenanthrene | Transient receptor potential channels | 9 Phenanthrol | NSC50554 | 9-Phenanthrol

相关产品: (Z)-Capsaicin | OMDM-6 | Methyl salicylate | AMG 517 | JC-229 | 8-Gingerol | cim0216 | Pinokalant | 1,4-Cineole | Englerin A

相关库: Ion Channel Inhibitor Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library

9-羟基菲 T22537信息由TargetMol中国为您提供，如您想了解更多关于9-羟基菲 T22537报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途