化合物Adaphostin T22553

Product Introduction
Bioactivity


英文名: Adaphostin

描述: Adaphostin (NSC-680410) 是 AG957 金刚烷酯，是一种 p210bcr/abl 抑制剂，可诱导 T 淋巴细胞白血病细胞系凋亡。它增加了 CLL B 细胞内活性氧的水平，对慢性和急性髓系白血病细胞具有显著的选择性活性。

体外活性: It also induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro.

体内活性: Adaphostin can damage both myeloid and lymphoid leukemia cells[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : < 40 mg/mL (101.66 mM)
DMSO : 55 mg/mL (139.78 mM)


关键字: NSC-680410 | Apoptosis | tyrosine kinase | NSC680410 | inhibit | Bcr-Abl | chronic myelogenous leukemia | myeloid | Adaphostin | Inhibitor | ROS | p210Bcr/abl | CML

相关产品: Rebastinib | Silybin B | Rigosertib | Vamotinib | Imatinib Mesylate | AG957 | AEE788 | XL228 | Imatinib | Nocodazole

相关库: ReFRAME Related Library | Anti-Cancer Compound Library | Angiogenesis related Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | Kinase Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Tyrosine Kinase Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途