化合物CHF5074 T2262

Product Introduction
Bioactivity


英文名: Itanapraced

描述: Itanapraced (CHF5074) 是新型γ-secretase 调节剂，能够降低 Aβ42 (IC50=3.6 nM) 和 Aβ40 (IC50=18.4 nM) 分泌。

激酶实验: GSK-3β activity assay: IC50 of new synthesised compound IM-12 to GSK-3β is determined by a luminometric GSK-3β activity assay. Briefly, compounds are tested in different concentrations diluted in assay buffer containing final concentrations of: 4 mM MOPS pH 7.2; 0.4 mM EDTA; 1 mM EGTA; 2.5 mM β-glycerophosphate; 4 mM MgCl2; 40 μM BSA; 0.05 mM DTT. Four microlitres of diluted compounds are added to 25 μM pGS-2 peptide substrate, 20 ng recombinant GSK-3β and 1 μM ATP to a total assay volume of 40 μl. The enzymatic reaction is stopped after 30 min of incubation at 30 °C by adding 40 μl KinaseGlo. The luminometric signal is allowed to stabilise for 10 min and the measured with a Glomax? 96 Microplate Luminometer.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 37 mg/mL


关键字: CSP 1103 | Inhibitor | CHF 5074 | Gamma secretase | γ-secretase | CSP1103 | Itanapraced | inhibit | CHF-5074

相关产品: PQM130 | BMS 433796 | β-Amyloid (1-42), human | Anatabine | TABERSONINE HYDROCHLORIDE | GSNKGAIIGLM(131602-53-4(free base)) | Amyloid β-Protein 10-20 acetate | Timosaponin BII | Saikosaponin C | TAE-1

相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-Parkinson's Disease Compound Library | ReFRAME Related Library | Clinical Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Preclinical Compound Library | NO PAINS Compound Library | Anti-Alzheimer's Disease Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途