化合物JW 67 T22884
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 442644-28-2 | ¥1,390.00 | 询底价 |
50 mg | 442644-28-2 | ¥4,370.00 | 询底价 |
5 mg | 442644-28-2 | ¥898.00 | 询底价 |
100 mg | 442644-28-2 | ¥6,230.00 | 询底价 |
1 mg | 442644-28-2 | ¥396.00 | 询底价 |
2 mg | 442644-28-2 | ¥569.00 | 询底价 |
25 mg | 442644-28-2 | ¥2,890.00 | 询底价 |
1 mL | 442644-28-2 | ¥983.00 | 询底价 |
Product Introduction
Bioactivity
英文名: JW 67
描述: JW 67 是典型 Wnt 信号通路的抑制剂,IC50为 1.17 μM。它影响由 β- 连环蛋白/GSK-3β/AXIN/APC/CK1 组成的多蛋白复合物,快速降低活性 β- 连环蛋白,随后下调Wnt 靶基因。它也抑制结直肠癌细胞生长。
体外活性: JW 67 inhibits the canonical?Wnt?signaling with an?IC50?of 1.17μM[1]. JW 67 (1 μM) increased concentration of AXIN2 and decreased the active form of β-catenin[1]. JW 67 (10 or 25μM) reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 60 mg/mL (152.14 mM)
关键字: inhibit | JW 67 | Wnt | Inhibitor | CK1 | complex | JW-67 | β-catenin | GSK-3b | JW67 | AXIN | multiprotein | APC
相关产品: ICG001 | Wnt pathway activator 2 | Windorphen | LF3 | K-756 | Urea | IWP-4 | NCB-0846 | Trachelogenin | NRX-252114
相关库: Anti-Prostate Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Cancer Compound Library | Neuronal Differentiation Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Anti-Colorectal Cancer Compound Library | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Active Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途