化合物PHA 543613 T23145

Product Introduction
Bioactivity


英文名: PHA 543613

描述: PHA 543613 是一种特异性 α7 nAChR 激动剂 (Ki = 8.8 nM) ，可用于阿尔茨海默病和精神分裂症认知缺陷的研究。

体内活性: In rats, PHA-543613 (0.3 mg/kg) reverses Scopolamine-induced short-term memory deficits[2]. Intraperitoneal injection of PHA-543613 (4 and 12 mg/kg) increases p-Akt and decreases p-GSK-3 and CC3 expressions in the ipsilateral hemisphere. PHA-543613 reduces neuronal cell death in the perihematomal area[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 225.0 mg/mL (829.3 mM)
H2O : < 30.78 mg/mL


关键字: PHA543613 | PHA-543613 | PHA 543613 hydrochloride | PHA 543613

相关产品: Thonzylamine hydrochloride | Facinicline hydrochloride | Tacrine | Clevidipine | VU0238441 | (S)-(+)-Dimethindene maleate | Agaric acid | Tiotropium bromide | A-867744 | PHA 568487 free base

相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途