盐酸RS67333 T23265

Product Introduction
Bioactivity


英文名: RS 67333 hydrochloride

描述: RS 67333 hydrochloride (RO5203648) 是一种有效的、选择性的5-HT4 受体 (5-HT4R) 部分激动剂，在豚鼠纹状体中的 pKi 为 8.7。RS 67333 hydrochloride 对其他几种受体的亲和力较低，包括 5-HT1A、5-HT1D、5-HT2A、5-HT2C、多巴胺 D1、D2 和毒蕈碱 M1-M3 受体。RS 67333 hydrochloride 具有神经保护作用，可用于阿尔茨海默病研究。

体外活性: RS 67333 hydrochloride exhibits affinities for the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 hydrochloride acts as a potent (pEC50 of 8.4), partial agonists (intrinsic activities, with respect to 5-HT is 0.5) with respect to 5-HT [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 9mg/ml (23.1mM)


关键字: RS67333 | RS 67333 Hydrochloride | RS-67333 | RS 67333 | RS-67333 Hydrochloride | RS67333 Hydrochloride

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相关库: Neurotransmitter Receptor Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Antidepressant Compound Library | Neuronal Signaling Compound Library | GPCR Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途