化合物(E/Z)-SIB-1893 T23353

Product Introduction
Bioactivity


英文名: (E/Z)-SIB-1893

描述: (E/Z)-SIB-1893 (SIB 1893)是 (E)-SIB-1893 和 (Z)-SIB-1893 的消旋体。(E)-SIB-1893 是一种选择性的、非竞争性的 mGluR5 拮抗剂，具有抗惊厥活性 。

体外活性: 我们研究了mGluR5在培养的大鼠皮层细胞中急性NMDA和谷氨酸介导的神经退行性病变中的作用，采用了mGluR5拮抗剂SIB-1893（20或200 μM；大鼠皮层细胞），发现它们能提供显著的保护。[4]

体内活性: SIB-1893 (10, 20, and 30 mg/kg; i.p.; 0-180 min) considerably lowered the body temperature in animals at 90, 120, and 180 min after its systemic injection of 30 mg/kg. In contrast, the drug at 10 and 20 mg/kg remained without effect on the body temperature in rats. Based on our preclinical study, one can conclude that SIB-1893 produces hypothermia in freely moving rats in a dose-dependent manner.[1]SIB 1893 (10 and 20 mg/kg; mice; i.p.) did not affect the protective action of valproate, ethosuximide, phenobarbital, and clonazepam in this test. The combined treatment of SIB 1893 with conventional antiepileptic drugs did not lead to motor impairment. Long-term memory disturbances were observed only in the case of the combination of SIB 1893 with phenobarbital.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 90.0 mg/mL (460.9 mM)


关键字: (E/Z)-SIB1893 | (E/Z)-SIB 1893 | SIB1893 | SIB-1893 | (E/Z)-SIB-1893

相关产品: Farampator | NPS2390 | Philanthotoxin 74 dihydrochloride | ABP688 | ADX-47273 | TCN238 | cis-PDA | Ro0711401 | Org-26576 | Decoglurant

相关库: Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Bioactive Compound Library

化合物(E/Z)-SIB-1893 T23353信息由TargetMol中国为您提供，如您想了解更多关于化合物(E/Z)-SIB-1893 T23353报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途