化合物 T23486 T23486
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | T23486 | ¥1,383.00 | 询底价 |
10 mg | T23486 | ¥2,283.00 | 询底价 |
25 mg | T23486 | ¥3,183.00 | 询底价 |
1 mg | T23486 | ¥483.00 | 询底价 |
Product Introduction
Bioactivity
英文名: ubiquitin specific protease 3 fragment
描述: The ubiquitin speci c protease 3 USP3 is a deubiquitinating enzyme for uH2A and uH2B.
体外活性: USP3 has been characterized as a functional DUB in vitro, and it is the human DUB most homologous to S. cerevisiae Ubp8, which regulates H2B deubiquitination2-4.
体内活性: USP3 dynamically associates with chromatin and deubiquitinates H2A/H2B in vivo. The ZnF-UBP domain of USP3 mediates uH2AUSP3 interaction. Functional ablation of USP3 by RNAi leads to delay of S phase progression and to the accumulation of DNA breaks, with ensuing activation of DNA damage checkpoint pathways. In response to ionizing radiation, (1) uH2A redistributes and colocalizes in g-H2AX DNA repair foci, and (2) USP3 is required for full deubiquitination of ubiquitin-conjugates/uH2A and g-H2AX dephosphorylation. USP3 is a novel regulator of H2A and H2B ubiquitination, highlight its role in preventing replication stress and suggest its involvement in the response to DNA double-strand breaks1.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : ≥93.7mg/mL
关键字: ubiquitin specific protease 3 fragment
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途