化合物YIL 781 T23543
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 875258-85-8 | ¥4,750.00 | 询底价 |
25 mg | 875258-85-8 | ¥3,320.00 | 询底价 |
100 mg | 875258-85-8 | ¥6,620.00 | 询底价 |
5 mg | 875258-85-8 | ¥1,080.00 | 询底价 |
1 mL | 875258-85-8 | ¥1,230.00 | 询底价 |
1 mg | 875258-85-8 | ¥428.00 | 询底价 |
10 mg | 875258-85-8 | ¥1,570.00 | 询底价 |
Product Introduction
Bioactivity
英文名: YIL 781
描述: YIL 781是一种选择性ghrelin 受体拮抗剂(GHS-R1a) (Ki = 17 nM)),对运动素受体显示出较弱的亲和力(K = 6 μ M)。YIL 781通过阻断胃饥饿素分泌对体内和体外胰岛素分泌改善体内葡萄糖稳态。
体外活性: Post-transcriptional suppression by Ghsr siRNA transfection and treatment with GHS-R antagonist, YIL781, both significantly attenuated the effects of ghrelin in RGC-5 cells.[1]
体内活性: YIL781 (ghrelin receptor antagonist; from 0.1 to 5 μg; i.t. pretreatment) markedly attenuated the ghrelin-induced hyperglycemic effect. The plasma insulin level was increased by ghrelin. The enhanced plasma insulin level by ghrelin was reduced by i.t. pretreatment with YIL781.[2] With YIL781 pretreatment, the accumulated radioactivity in the pancreas 15-60min after [11C]3 injection was significantly decreased to 78% of control.[3]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 40.1 mg/mL (90.0 mM)
H2O : 40.1 mg/mL (90.0 mM)
关键字: YIL 781 | YIL-781 | YIL781
相关产品: Cortistatin-8 acetate | AnaMorelin hydrochloride | TM-N1324 | Emoghrelin | Human growth hormone-releasing factor acetate | Relamorelin | Anamorelin | hGPR91 antagonist 1 | NF-56-EJ40 hydrochloride | PF-5190457
相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途