丙烯菊酯 T25049

Product Introduction
Bioactivity


英文名: Allethrin

描述: Allethrin 是拟除虫菊酯杀虫剂，是主要的驱蚊剂。它在大鼠睾丸癌细胞 (LC540) 中诱导氧化应激、细胞凋亡和钙释放。它还诱导 BCL-2、caspase-3 激活和细胞内钙的释放。

体外活性: Allethrin (125 μM) induces BCL-2, caspase-3 activation and release of intracellular calcium[1]. Morphological analyses of LC540 cells treated with Allethrin (125 μM) reveals the presence of apoptotic bodies. The percentage of cells displaying early apoptotic features increased significantly[1].

体内活性: In male wistar rats aged 90 day,s Allethrin (25, 50, 100, and 150 mg/kg; every day for 60 days) increased lipid peroxidation in the caput, cauda, and testes[3]. Significant increase in catalase activity was observed in the cauda obtained from 50, 100, and 150 mg/kg. GPx activity was significantly increased in the caput obtained from 150 mg/kg treated rats. In the cauda, it was found to be increased significantly in the 50 and 100 mg/kg treated groups. In contrast, the activity of GPx activity was significantly decreased in the testes of rats treated with 150 mg/kg. GST activity was found to be increased significantly in a dose dependent manner in the caput and cauda of allethrin treated rats[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/ml (198.41 mM)


关键字: mosquito | calcium | release | Allethrin | sperm | maturation | insecticide | inhibit | Apoptosis | repellent | epididymis | Pyrethroid | stress | Inhibitor | testis | oxidative

相关产品: Safflor Yellow A | BAM7 | Lisaftoclax | Clitocine | BI-3812 | Metaproterenol | BI-3802 | MIM1 | TW-37 | (S)-(+)-Ibuprofen

相关库: Pyroptosis Compound Library | Mitochondria-Targeted Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | PPI Inhibitor Library | Cuproptosis Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途