群司卡尼 T26287
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 88296-62-2 | ¥1,870.00 | 询底价 |
25 mg | 88296-62-2 | ¥9,890.00 | 询底价 |
50 mg | 88296-62-2 | ¥13,300.00 | 询底价 |
500 mg | 88296-62-2 | ¥35,900.00 | 询底价 |
5 mg | 88296-62-2 | ¥4,630.00 | 询底价 |
100 mg | 88296-62-2 | ¥17,800.00 | 询底价 |
10 mg | 88296-62-2 | ¥6,590.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Transcainide
描述: Transcainide(R 54718) 是一种新的利多卡因类似物,是具有口服活性的抗心律失常剂。Transcainide 可阻断牛心脏和大鼠骨骼肌中 BTX 激活的钠通道的开放状态。
体外活性: Transcainide (IC50=0.3 μM) inhibited equilibrium [3H]batrachotoxinin binding to sodium channels present on freshly isolated rat cardiac myocytes. Scatchard analysis of [3H]batrachotoxinin binding showed that Transcainide both reduced maximal binding and altered the KD for [3H]batrachotoxinin binding, indicating noncompetitive, allosteric inhibition. Inhibition by Transcainide of [3H]batrachotoxinin binding was reversible within 60 min. Transcainide had little effect on the k-1 of [3H]batrachotoxinin even at concentrations 1000-fold greater than its IC50, indicating a low affinity of Transcainide for activated channels. However, Transcainidee decreased the k + 1 of [3H]batrachotoxinin at a concentration very close to its IC50 concentration for inhibiting equilibrium [3H] batrachotoxin binding. The results are discussed in terms of a model in which Transcainide inhibits [3H] batrachotoxin binding by binding specifically to and stabilizing a nonactivated state of the cardiac sodium channel.[1]Reduction of sodium current by Transcainide was concentration-dependent, with an ED50 of approximately 0.5 μM (n = 9).[2]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 3.74 mg/mL (10 mM)
关键字: Transcainide
相关产品: µ-Conotoxin KIIIA | Permethrin | Benzocaine xHCl(94-09-7(free base)) | µ-Conotoxin BuIIIC | Nav1.8-IN-1 | (5R)-BW-4030W92 | Phlotoxin-1 | DSP-2230 | Pilsicainide HCl | Jingzhaotoxin-34
相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途