曲帕拉醇 T26296
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 78-41-1 | ¥4,720.00 | 询底价 |
10 mg | 78-41-1 | ¥5,930.00 | 询底价 |
5 mg | 78-41-1 | ¥4,400.00 | 询底价 |
1 mg | 78-41-1 | ¥1,890.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Triparanol
描述: Triparanol (NSC-65345) 干扰 Hedgehog 信号分子的翻译后修饰以及其受体 PTCH1 的甾醇传感域,导致 Hedgehog 信号的下调。 Triparanol 抑制人类肿瘤生长,是一种具有高眼毒性的抗血脂剂。
体外活性: Triparanol is an effective cholesterol biosynthesis inhibitor blocking the 24-dehydrocholesterol reductase. Triparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer, and melanoma cells, and growth inhibition can be rescued by the exogenous addition of cholesterol[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (114.16 mM)
关键字: PTCH1 | Hedgehog | 24-DHCR | cholesterol biosynthesis | inhibit | MER 29 | Apoptosis | tumor growth | Inhibitor | MER29 | Triparanol
相关产品: Stavudine | Chelidonine | Cobimetinib | BTT-3033 | Oxibendazole | DAPT | Sesamol | SAR125844 | TAS6417 | R406
相关库: Anti-Prostate Cancer Compound Library | Anti-Cancer Compound Library | Neuronal Differentiation Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | GPCR Compound Library | Stem Cell Differentiation Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途