化合物Pitstop 2 T26357

Product Introduction
Bioactivity


英文名: Pitstop 2

描述: Pitstop2 是一种选择性的两性蛋白结合的网格蛋白末端结构域抑制剂，IC50 值为 12 μM。 Pitstop2 严重干扰受体介导的内吞作用、HIV 进入和突触小泡循环。

体外活性: Pitstop2 potently and specifically reduced HIV-1 infectivity by >90% in HeLa cells. Preincubation of HeLa cells with Pitstop2 (Pitstops 2) leads to a dose-dependent inhibition of Tf uptake with an IC50 value (12-5 μM). Application of 30 μM Pitstop2 completely blocked Tf endocytosis. Pitstop2-induced block of Tf endocytosis in HeLa cells was completely reversed within 1-3 hr of drug washout. In U2OS cells, the IC50 for Tf uptake is 9.7 μM. Pitstop 2 also causes a potent inhibition of EGF uptake[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 6.88 mg/mL (14.52 mM)


关键字: Pitstop 2 | cancer | Pitstop2 | Pitstop-2 | endocytosis | clathrin-mediated | inhibit | CME | Inhibitor | Apoptosis | clathrin

相关产品: Wogonin | Colchicine | PHA-767491 hydrochloride | AT9283 | Tributyrin | Isatuximab | NVP-TNKS656 | YUM70 | ARS-853 | Buparlisib

相关库: Apoptosis Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途