川续断皂苷 VI T2698

Product Introduction
Bioactivity


英文名: Asperosaponin VI

描述: Asperosaponin VI (Akebia saponin D) 是一种来自续断壁的皂苷组分。它通过增加 Bcl-2/Bax 比值，降低活性 caspase-3 表达，以及增强 p-Akt 和 p-CREB，从而抑制缺氧诱导的心肌细胞凋亡。它通过 BMP-2/p38 和 ERK1/2 信号途径诱导成骨细胞分化。

激酶实验: Cells are grown on 12-mm diameter glass coverslips in DMEM 100% serum and various concentrations of KN-93 or KN-92. After 0, 1, 2, and 3 days of culture in the presence of drug, coverslips are removed from culture, rinsed once in PBS, and then submerged in 100% methanol at -20°C for 3 min. Fixed cells are stored in PBS until staining using the TUNEL assay. Cells are overlaid on 20 μL PBS/1 mg/mL BSA for 30 min, rinsed in PBS, and then overlaid on 20 μL containing 100 mM sodium cacodylate (pH 6.8), 1 mM CoCl2, 0.1 mM DTT, 0.1 mg/mL BSA, 20 μM fluorescein-12-dUTP, and 0.1 unit/μL terminal transferase at 37°C for 60 min. Coverslips are rinsed in PBS twice, mounted on slides, and photographed using an OLYMPUS BX5O epifluorescent microscope using a UPLAN APO 40X oil immersion objective.

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (26.91 mM)


关键字: inhibit | Apoptosis | Inhibitor | Caspase | Asperosaponin VI

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相关库: Terpene Natural Product Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Osteogenesis Compound Library | Traditional Chinese Medicine Monomer Library | Apoptosis Compound Library | Anti-COVID-19 Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | NO PAINS Compound Library | Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途