化合物DPI 201-106 T27205

Product Introduction
Bioactivity


英文名: DPI 201-106

描述: DPI 201-106对电压门控钠通道的有心脏选择性调节活性，从而产生正性肌力作用。DPI 201-106 具有协同肌膜和细胞内作用机制。

体外活性: DPI 201-106(0.1 - 3 μM) produces concentration-dependent positive inotropic effects in guinea-pig and rat left atria, kitten, rabbit and guinea-pig papillary muscles and Langendorff perfused hearts of rabbits[2]. DPI 201-106 increases the Ca2+ sensitivity(EC50 = 0.2 nM) of skinned fibres from porcine trabecula septomarginalis[2].

体内活性: DPI 201-106(0.2 mg/kg i.v)给药能增加麻醉犬左心室最大压力上升速率(dP/dtmax)[3]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 250 mg/mL (535.83 mM)


关键字: SDZ 201106 | SDZ201106 | DPI 201 106 | DPI 201106 | Na channels | SDZ-201106 | inhibit | DPI201-106 | Na+ channels | Sodium Channel | Inhibitor | DPI 201-106

相关产品: Hydroquinidine | Metaflumizone | Piromelatine | Veratramine | PF 05089771 tosylate | Ralfinamide mesylate | Flunarizine dihydrochloride | Etidocaine Hydrochloride | Bupivacaine hydrochloride | Rufinamide

相关库: Ion Channel Inhibitor Library | ReFRAME Related Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途