艾罗非班 T27250
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 198958-88-2 | ¥6,860.00 | 询底价 |
100 mg | 198958-88-2 | ¥25,500.00 | 询底价 |
25 mg | 198958-88-2 | ¥13,800.00 | 询底价 |
50 mg | 198958-88-2 | ¥18,900.00 | 询底价 |
1 mg | 198958-88-2 | ¥2,960.00 | 询底价 |
10 mg | 198958-88-2 | ¥9,430.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Elarofiban
描述: Elarofiban(RWJ-53308) 是一种新型且具有口服活性的 GPIIb/IIIa 拮抗剂。
体外活性: Elarofiban (RWJ-53308) is a novel nonpeptide glycoprotein IIb/IIIa (GPIIb/IIIa) antagonist that inhibits fibrinogen binding to GPIIb/IIIa with an IC(50) of 0.4+/-0.3 nM. RWJ-53308 inhibits thrombin-induced platelet aggregation in human gel-filtered platelets (IC(50)=60+/-12 nM) and platelet aggregation in human platelet-rich plasma (PRP) in response to collagen, arachidonic acid, ADP, and SFLLRN-NH(2) (IC(50)=60+/-10, 150+/-30, 70+/-4, and 160+/-80 nM, respectively).[4]
体内活性: The potency of Elarofiban (RWJ-53308) in dog and guinea pig PRP is similar to human PRP. RWJ-53308 inhibits ex vivo collagen- and ADP-induced platelet aggregation in conscious dogs for up to 4 h following 0.3 mg/kg iv, and through 4 and 6 h following 1 and 3 mg/kg po. Oral bioavailability is 16+/-7%. RWJ-53308 reduces thrombus weight in a canine arteriovenous (AV) shunt model following intravenous (0.01-0.1 mg/kg) and oral (3 mg/kg) administration. In a guinea pig carotid artery pinch-injury model, RWJ-53308 completely suppresses thrombus-induced cyclic flow reductions (CFR) at 0.7 mg/kg iv. RWJ-53308 also blocks thrombus formation in photoactivation- and ferric chloride-induced models of thrombosis in guinea pigs at 0.3 and 1 mg/kg iv, respectively. In summary, RWJ-53308 is a potent orally active GPIIb/IIIa antagonist that may be useful for both acute and chronic treatment of arterial thrombotic disorders.[4]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 60 mg/mL (144.05 mM)
关键字: Elarofiban
相关产品: Carvedilol phosphate hemihydrate | E7820 | iRGD peptide | LXW7 TFA (1313004-77-1 free base) | OSU-T315 | αvβ1 integrin-IN-2 | VnP-16 | Cucurbitacin B | Egaptivon pegol | ILK-IN-2
相关库: Bioactive Compounds Library Max | Bioactive Compound Library
艾罗非班 T27250信息由TargetMol中国为您提供,如您想了解更多关于艾罗非班 T27250报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途