化合物Emivirine T27260

Product Introduction
Bioactivity


英文名: Emivirine

描述: Emivirine (MKC-442) 是一种有效和选择性的人类免疫缺陷病毒1型(HIV-1)的非核苷逆转录酶抑制剂。

体外活性: Emivirine is a novel nonnucleoside reverse transcriptase inhibitor that displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity in vivo. IC50 against laboratory-adapted strains of HIV-1 ranged from 1.6 to 19 nM. Against clinical isolates, the IC50 for EMV ranged from 2 to 40 nM. The Ki values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively[1].

体内活性: Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity in vivo. Pharmacokinetics were linear for both rats and monkeys, and oral absorption was 68% in rats. Rats were given an oral dose of Emivirine at 10 mg/kg of body weight showed widespread distribution in tissue after 30 min. In rats given an oral dose of 250 mg/kg, there were equal levels of Emivirine in the plasma and the brain[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 4.8 mg/mL (15.87 mM)


关键字: Emivirine

相关产品: Morolic acid | Atazanavir sulfate | Tsugafolin | HIV-1 protease-IN-7 | Helichrysetin | Apigenin 7-glucoside | Cepharanthine | Daurichromenic acid | HIV-IN-6 | Salmeterol Xinafoate

相关库: Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Viral Compound Library | Bioactive Compound Library

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