化合物Facinicline hydrochloride T28531

Product Introduction
Bioactivity


英文名: Facinicline hydrochloride

描述: Facinicline hydrochloride (RG3487) 是一种口服有效的烟碱α7 receptor 部分激动剂，对人 nAChR 的 Ki 值为 6 nM。它可改善啮齿类动物的认知和感觉运动门控。它与5-HT3受体结合的 Ki 为 1.2 nM。

体外活性: Facinicline hydrochloride exhibits antagonist properties at the serotonin 3 receptor in oocytes(IC50 = 2.8 μM) and N1E-115 cells(IC50 = 32.7 μM)[2].Facinicline hydrochloride activates human α7 nAChRs in oocytes(EC50 = 0.8 μM) and QM7 cells(EC50 = 7.7 μM)[2].

体内活性: In Male Sprague-Dawley rats, Facinicline hydrochloride (0.1–10 mg/kg p.o.) selectively enhances object recognition memory[1]. Facinicline hydrochloride improves object recognition memory in rats after acute(1.0 mg/kg p.o.) or repeated (10 day) administration at brain and plasma concentrations in the low-nanomolar range[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 100 mg/mL (325.96 mM)
DMSO : 125 mg/mL (407.44 mM)


关键字: Inhibitor | nAChR | serotonin 3 receptor | Facinicline Hydrochloride | Nicotinic acetylcholine receptors | Serotonin Receptor | RG-3487 | 5-HT Receptor | inhibit | recognition | 5-hydroxytryptamine Receptor | RG 3487 | Facinicline | Facinicline hydrochloride | receptor | memory | nicotinic

相关产品: 5-HT2C agonist-3 free base | AMI-193 | 6-fluoro-DL-Tryptophan | alpha-Yohimbine | Naluzotan | PU02 | Cyclobenzaprine hydrochloride | Fluoxetine hydrochloride | AL 34662 | JNJ-18038683

相关库: Neurotransmitter Receptor Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | GPCR Compound Library | Serotonin Receptor-Targeted Compound Library | Orally Active Compound Library | Bioactive Compound Library

化合物Facinicline hydrochloride T28531信息由TargetMol中国为您提供，如您想了解更多关于化合物Facinicline hydrochloride T28531报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途