漆黄素 T2879

Product Introduction
Bioactivity


英文名: Fisetin

描述: Fisetin 是在许多水果和蔬菜中发现的一种天然黄酮醇，有抗氧化、抗癌和神经保护作用。

体外活性: Fisetin (3,7,3',4'-tetrahydroxyflavone) is a naturally found flavonol in many fruits and vegetables and is known to have anti-aging, anti-cancer and anti-viral effects. Fisetin inhibits lipid accumulation and suppresses the expression of PPARγ in 3T3-L1 cells. Fisetin suppressed early stages of preadipocyte differentiation, and induced expression of Sirt1. Depletion of Sirt1 abolished the inhibitory effects of fisetin on intracellular lipid accumulation and on PPARγ expression. Mechanistically, fisetin facilitated Sirt1-mediated deacetylation of PPARγ and FoxO1, and enhanced the association of Sirt1 with the PPARγ promoter, leading to suppression of PPARγ transcriptional activity, thereby repressing adipogenesis. Lowering Sirt1 levels reversed the effects of fisetin on deacetylation of PPARγ and increased PPARγ transactivation[1].

体内活性: Pretreatment with fisetin significantly alleviated the elevated levels of serum creatinine and blood urea nitrogen in LPS-treated mice. Consistently, LPS induced renal damage as implied by histopathological score and the increased injury markers NGAL and KIM-1, which was attenuated by fisetin. Meanwhile, LPS injection triggered proinflammatory cytokine production and inflammation related proteins in the kidneys. However, fisetin inhibited renal expression of IL-6, IL-1β, TNF-α, HMGB1, iNOS and COX-2 to improve inflammatory response. Furthermore, fisetin effectively reduced the number of TUNEL positive apoptotic cells and suppressed apoptotic protein of Bcl-2, BAX and cleaved caspase-3 in the kidneys of LPS-induced septic AKI[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 28.6 mg/mL (100 mM)
5% DMSO+95% Saline : 1.43 mg/mL (5 mM, suspension)
Ethanol : 2.9 mg/mL (10 mM)


关键字: PPAR | inhibit | TNF Receptor | Tumor Necrosis Factor Receptor | TNFR | Fisetin | Inhibitor | Peroxisome proliferator-activated receptors | Sirtuin

相关产品: LASSBio-1135 | 11-Hydroxytephrosin | HOMOPLANTAGININ | Linarin | 5-Hydroxy-7,8-dimethoxyflavanone | Geraniin | SKF-86002 | Hyuganin D | Ganoderic acid C1 | Hernandezine

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-Breast Cancer Compound Library | Polyphenolic Natural Product Library | Anti-Cancer Drug Library | Bioactive Compounds Library Max | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Miao medicine Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途