化合物5-Hydroxydecanoate sodium T29457L

Product Introduction
Bioactivity


英文名: 5-Hydroxydecanoate sodium

描述: 5-Hydroxydecanoate sodium 是一种选择性 ATP 敏感的 K+ (KATP) 通道阻滞剂，IC50 约为 30 μM。 它是线粒体外膜酰基辅酶A 合成酶的底物，具有抗氧化性。

体外活性: The treatment of 5-Hydroxydecanoate sodium abolished the beneficial effects of penehyclidine hydrochloride (PHC) preconditioning in anoxia/reoxygenation (A/R)‐induced injury in H9c2 cells. 5-Hydroxydecanoate sodium blocked the inhibitory effect of PHC on Ca2+ overload and ROS production and promoted the release of Cyt-C from mitochondria into cytoplasm. 5-Hydroxydecanoate sodium attenuated the anti-apoptotic effect of PHC[1].

体内活性: The treatment of 5-Hydroxydecanoate sodium (100 μM) abolished the effects of ischemic preconditioning (IPC) on the contractile recovery, but 5-Hydroxydecanoate sodium did not affect its effect on the contracture, lactate production, glycogenolysis and viable tissue in rats[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.6 mg/mL (17.12 mM)


关键字: 5 Hydroxydecanoate sodium | 5Hydroxydecanoate sodium | 5-Hydroxydecanoate sodium

相关产品: Vernakalant Hydrochloride | Rosuvastatin calcium | Cesium chloride | AVE-0118 | Tolbutamide | Tipepidine hydrochloride | N-Acetylprocainamide | DPO-1 | Dihydroisotanshinone I | Branaplam

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